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Without intrinsic factor, people develop vitamin B12 deficiency, with symptoms such as fatigue, a distinctive change in red blood cells, nausea, indigestion and other digestive problems, weakness, headaches and weight loss

B12 deficiency can cause fatigue, weakness, and brain fog, symptoms some people experience during early semaglutide treatment as their body adjusts to reduced food intake

It plays a role in preventing fatigue, supports mental health, and is implicated in the prevention of diseases such as heart disease and certain types of cancer